The use of supramolecular structures as protein ligands.
作者： Barbara Stopa , Anna Jagusiak , Leszek Konieczny , Barbara Piekarska , Janina Rybarska
DOI: 10.1007/S00894-012-1744-1
关键词: Antigen-Antibody Complex 、 Congo red 、 Activity profile 、 Molecular stability 、 Stereochemistry 、 Supramolecular chemistry 、 Molecule 、 Biophysics 、 Organic molecules 、 Chemistry 、 Protein ligand
摘要: Congo red dye as well other eagerly self-assembling organic molecules which form rod-like or ribbon-like supramolecular structures in water solutions, appears to represent a new class of protein ligands with possible wide-ranging medical applications. Such associate proteins integral clusters and preferentially penetrate into areas low molecular stability. Abnormal, partly unfolded are the main binding target for such ligands, while packed generally inaccessible. Of particular interest is observation that local susceptibility may be promoted some consequence function-derived structural changes, complexation alter activity profile proteins. Examples presented this paper.
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