Defined sequence segments of the small heat shock proteins HSP25 and αB-crystallin inhibit actin polymerization
作者： Martin Wieske , Rainer Benndorf , Joachim Behlke , Rudolf Dölling , Gerlinde Grelle
DOI: 10.1046/J.1432-1327.2001.02082.X
关键词: Peptide 、 Actin-binding protein 、 Polymerization 、 Cell biology 、 Phosphorylation 、 Chemistry 、 Serine 、 In vivo 、 Inhibitory postsynaptic potential 、 Actin 、 Biochemistry
摘要: N-terminally extended peptide 11 at serine residues known to be phosphorylated in vivo resulted decline of their inhibitory activity. Interestingly, peptides derived from the homologous sequence murine aB-crystallin showed same behaviour. The results suggest that both HSP25 and have potential inhibit actin polymerization this activity is regulated by phosphorylation.
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Stefano Longoni, Sari Lattonen, Gillian Bullock, Michele Chiesi, Cardiac alpha-crystallin. II. Intracellular localization. Molecular and Cellular Biochemistry. ,vol. 97, pp. 121- 128 ,(1990) , 10.1007/BF00221053
Shigeko Yamashiro, Yoshihiko Yamakita, Ryoki Ishikawa, Futnio Matsumura, Mitosis-specific phosphorylation causes 83K non-muscle caldesmon to dissociate from microfilaments Nature. ,vol. 344, pp. 675- 678 ,(1990) , 10.1038/344675A0
Thomas D. Pollard, Measurement of rate constants for actin filament elongation in solution Analytical Biochemistry. ,vol. 134, pp. 406- 412 ,(1983) , 10.1016/0003-2697(83)90316-0
Kanefusa Kato, Hidenori Ito, Keiko Kamei, Yutaka Inaguma, Ikuko Iwamoto, Shinsuke Saga, Phosphorylation of αB-crystallin in Mitotic Cells and Identification of Enzymatic Activities Responsible for Phosphorylation Journal of Biological Chemistry. ,vol. 273, pp. 28346- 28354 ,(1998) , 10.1074/JBC.273.43.28346
T Miron, K Vancompernolle, J Vandekerckhove, M Wilchek, B Geiger, A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein. Journal of Cell Biology. ,vol. 114, pp. 255- 261 ,(1991) , 10.1083/JCB.114.2.255
Peter J.Del Vecchio, Kelly S. Macelroy, Mary P. Rosser, Robert L. Church, Association of alpha-crystallin with actin in cultured lens cells. Current Eye Research. ,vol. 3, pp. 1213- 1219 ,(1984) , 10.3109/02713688409000824
Matthias GAESTEL, Burckhard GROSS, Rainer BENNDORF, Michael STRAUSS, Wolf-Hagen SCHUNK, Regine KRAFT, Albrecht OTTO, Hans BOHM, Joachim STAHL, Heinz DRABSCH, Heinz BIELKA, Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins. FEBS Journal. ,vol. 179, pp. 209- 213 ,(1989) , 10.1111/J.1432-1033.1989.TB14542.X
J. Horwitz, Alpha-crystallin can function as a molecular chaperone Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 10449- 10453 ,(1992) , 10.1073/PNAS.89.21.10449
R. Klemenz, E. Frohli, R. H. Steiger, R. Schafer, A. Aoyama, Alpha B-crystallin is a small heat shock protein. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 3652- 3656 ,(1991) , 10.1073/PNAS.88.9.3652
Martin Bähler, Paul Greengard, Synapsin I bundles F-actin in a phosphorylation-dependent manner. Nature. ,vol. 326, pp. 704- 707 ,(1987) , 10.1038/326704A0