Determination of poly(ɛ-caprolactone) solubility parameters: Application to solvent substitution in a microencapsulation process

摘要: The evolution of regulation on chemical substances (i.e. REACH regulation) calls for the progressive substitution toxic chemicals in formulations when suitable alternatives have been identified. In this context, method Hansen solubility parameters was applied to identify an alternative solvent less than methylene chloride used a microencapsulation process. During process based multiple emulsion (W/O/W) with evaporation/extraction method, has dissolve polymer, poly(epsilon-caprolactone) (PCL), which forms polymeric matrix encapsulating or entrapping therapeutic protein as is extracted. Therefore three partial PCL determined by group contribution swelling experiments and turbidimetric titration. results obtained allowed us find solvent, anisole, able solubilize form aqueous solutions. A feasibility test conducted under standard operating conditions production microspheres.