Dietary selenate attenuates adiposity and improves insulin sensitivity in high-fat diet-induced obese mice

摘要: Abstract Selenium is an essential micronutrient required for maintaining cellular redox homeostasis. Despite its potential beneficial role in lowering the risk of type 2 diabetes humans with lower selenium status and diabetic mice, preventing development obesity metabolic syndrome unknown. Here, we report that chronic selenate supplementation to high fat (HF) diet-fed mice resulted resistance diet-induced adiposity insulin resistance. The body weight adipose tissue mass gain associated HF was abrogated by at 0.72 mg/kg weight. This accompanied alteration expression genes involved adipokines, inflammation, transforming growth factor-β (TGF-β) signalling, mitochondria function, beige adipocyte differentiation tissue. Selenate also increase faecal calorie content improved glucose tolerance obese mice. Collectively this study elucidated a novel as dietary micromineral prevention related energy dysfunction.