Gnaq and Gna11 in the Endothelin Signaling Pathway and Melanoma.

摘要: In this article, we first briefly outline the function of G protein coupled receptors in cancer, and then specifically examine roles seven transmembrane Endothelin B receptor (Ednrb) proteins, GNAQ GNA11, both melanocyte development melanoma. Ednrb plays an essential role development. GNA11 are oncogenes when mutated certain types melanocytic lesions, being extremely frequent uveal melanoma, which forms from melanocytes located eye. Previously, reported that mice, Schwann cell precursor derived colonize dermis hair follicles, while inter-follicular epidermis is populated by other melanocytes. A pattern has emerged whereby whose activities affected gain-of-function mutations 3 ligand Gαq/11 same subset arise precursors. Furthermore, forced expression constitutively active human GNAQ(Q209L) oncogene mouse only causes hyper-proliferation This led us to hypothesize melanocytes, signals through Gαq/11. promiscuous may signal alpha subunits melanomas epidermis.