Controlled release formulation of tolterodine
作者： Dafna Arieli , Tomer Gold
DOI:
关键词: Controlled release 、 Population 、 Pharmacology 、 Chromatography 、 Relative humidity 、 Chemistry 、 Tolterodine 、 Excipient 、 Dissolution
摘要: The invention encompasses stable multiparticulate pharmaceutical compositions of tolterodine having at least one pharmaceutically acceptable excipient and two populations multiparticulates each population or a salt thereof the ratio is from 90:10 to 10:90 by weight, wherein after storage for 1 month 40 °C 75 % relative humidity difference between dissolution profile 4 hours no more than about 5 when compared time manufacture.
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