Leptin Receptor as a Potential Target to Inhibit Human Testicular Seminoma Growth.

摘要: Although in past decades the adipokine leptin and its own receptor have been considered as significant cancer biomarkers, their potential involvement human testicular seminoma growth progression remains unexplored. Here, we showed that expression of was significantly higher compared with normal adult testis. Human cell line TCam-2 also expressed along long short isoforms receptor, response to treatment enhanced activation downstream effectors. In these results, stimulation increased proliferation migration cells. Treatment cells peptide Leu-Asp-Phe-Ile (LDFI), a full leptin-receptor antagonist, completely reversed leptin-mediated effects on motility well reduced several leptin-induced target genes. More importantly, in vivo xenograft experiments LDFI markedly decreased tumor growth. Interestingly, LDFI-treated tumors levels marker Ki-67 leptin-regulated Taken together, data identify, for first time, key factor able affect behavior, highlighting novel treatments this type cancer.