Micelle-Enabled One-Pot Guanidine Synthesis in Water Directly from Isothiocyanate using Hypervalent Iodine(III) Reagents under Mild Conditions.
作者： Jakkrit Srisa , Theeranon Tankam , Mongkol Sukwattanasinitt , Sumrit Wacharasindhu
关键词: Solvent 、 Isothiocyanate 、 Guanidine 、 Pulmonary surfactant 、 Reagent 、 Micelle 、 Chemistry 、 One-pot synthesis 、 Organic chemistry 、 Aqueous solution
摘要: In this work, we developed a one-pot synthesis of guanidine directly from isothiocyanate using DIB (diacetoxyiodobenzene) as desulfurizing agent under micellar conditions in water. Our optimization study revealed that the use 1 % TPGS-750-M surfactant with NaOH an additive base at room temperature can convert variety isothiocyanates and amines into corresponding guanidines excellent yields (69-95 %). This synthetic process water be applied to prepare gram-scale quantity. aqueous medium also demonstrated high reusability reaction performed for several cycles without losing its efficiency. The is metal-free, utilizes solvent practical (room open flask).
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