Betulin protects mice from bacterial pneumonia and acute lung injury.

摘要: Betulin, a naturally occurring triterpene, has shown anti-HIV activity, but details on the anti-inflammatory activity are scanty. In this study, we sought to investigate effect of Betulin LPS-induced activation cell lines with relevance for lung inflammation in vitro and elicited by either LPS or viable Escherichia coli (E. coli) vivo. vitro, inhibited tumor necrosis factor α (TNF-α) (interleukin) IL-6 levels up-regulated level IL-10. Also suppressed phosphorylation nuclear factor-κB (NF-κB) p65 protein LPS-stimulated RAW 264.7 cells. vivo, alleviated acute injury. Treatment diminished pro-inflammatory cytokines, myeloperoxidase bacterial loads tissue during gram-negative pneumonia. Our findings demonstrated that inhibits responses induced stimuli E. coli, suggesting may represent novel strategy treatment inflammation.