Morphological Analysis of Ghrelin Neurons in the Hypothalamus
作者： Haruaki Kageyama , Fumiko Takenoya , Seiji Shioda
DOI: 10.1016/B978-0-12-381272-8.00006-4
关键词: Arcuate nucleus 、 Neuroscience 、 Proopiomelanocortin 、 Hypothalamus 、 Internal medicine 、 Endocrinology 、 Biology 、 Orexin 、 Immunoelectron microscopy 、 Ghrelin 、 Neuropeptide Y receptor 、 Neuron
摘要: Ghrelin, which is mainly produced in the A/X-like cells of oxyntic glands stomach, transduces an appetite-stimulatory signal from peripheral tissues to central nervous system. Ghrelin also localized hypothalamic arcuate nucleus rodents. While ghrelin acts on hypothalamus promote feeding behavior and energy metabolism, it important clarify neuronal circuits that involve so as elucidate action brain. Immunoelectron microscopy reveals neurons send synaptic outputs other feeding-regulating (e.g., containing orexin, proopiomelanocortin, or neuropeptide Y) receive inputs (proopiomelanocortin Y). This chapter describes immunohistochemical techniques employed interactions between kinds peptide-containing based evidence at both light microscopic ultrastructural levels.
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