Transdermal delivery of narcotic analgesics: pH, anatomical, and subject influences on cutaneous permeability of fentanyl and sufentanil.

摘要: The permeation of fentanyl and sufentanil through cadaver skin membranes was investigated using in vitro diffusion cell techniques. Neither drug influenced the other when they were concurrently applied to membrane. With respect transdermal delivery, short lag times less than 0.5 hr observed for each compound. Their rates heat-isolated epidermis dermatomed (200- 250-µm) sections essentially same. However, stratum corneum removed by tape stripping, respective permeability coefficients increased >30-fold, establishing as principal barrier their permeation. Permeation also studied a function pH. From pH 4 8 both sufentanil, calculated from total solution concentration regardless ionization, exponentially. free base is thus responsible relatively facile these drugs. Factoring independent ionized free-base forms possible, with latter being over two log orders larger seen protonated species. Permeability obtained different cadavers varied four- fivefold. gender nor age flux-determining variable either drug. drugs sites diverse sole foot, chest, thigh, abdomen remarkably similar. fluxes sufficient administration.