Dissolution of Amorphous Solid Dispersions: Theory and Practice
作者： Nikoletta Fotaki , Chiau Ming Long , Kin Tang , Hitesh Chokshi
DOI: 10.1007/978-1-4939-1598-9_15
关键词: Materials science 、 Dissolution testing 、 Weak base 、 Amorphous solid 、 Dissolution 、 Dispersion (chemistry) 、 Dosage form 、 Precipitation (chemistry) 、 Supersaturation 、 Chemical engineering
摘要: Dissolution test is an extremely valuable and powerful tool in understanding the parameters that control dissolution of amorphous formulations as well revealing supersaturation effect solid-state transformations might occur after oral administration. Supersaturated/non-sink biorelevant conditions could guide designing solid dispersion order to select optimal polymer(s), drug loading, downstream processing for desired vivo performance shelf life stability. The focus this chapter review describe different models being used characterize dosage forms containing drugs aqueous media. case studies weak base, acid, neutral compounds are presented, illustrating a rational approach development implementation characteristics product performance. Finally, successful vitro–in correlations presented. This can serve guidance dispersions.
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