Hepatits B and C Treatment in Renal Transplanted Patient

作者: Renata de Mello Perez

DOI:

关键词: GastroenterologyLamivudineHepatitis BVirologyHepatitis CNephrotoxicityInternal medicineEntecavirTransplantationMedicineHBsAgAdefovir

摘要: Em transplantados renais com anti-HCV ou HBsAg positivo, o tratamento esta indicado nos casos que apresentam evidencias de replicacao viral e padrao histologico hepatite cronica atividade necro-inflamatoria fibrose septal. O tambem pacientes reativacao da B apos transplante renal. Ate momento, a lamivudina tem sido principal droga utilizada para em renais. adefovir pode representar uma opcao os resistencia lamivudina. Nestes casos, fundamental manter cuidadosa monitorizacao funcao renal deteccao precoce eventual nefrotoxicidade. entecavir podera melhor terapeutica inicial renais, devido ao menor risco nefrotoxicidade tratamento. Entretanto, experiencia uso nesse grupo especifico ainda muito limitada. Nao estabelecido C A ribavirina ser alternativa maior gravidade histologica. Nos for utilizada, monitorizar niveis hemoglobina. nao deve administrada quando clearance creatinina 50mL/min. Palavras-chaves: B, C, In HCV or HBV infected transplanted patients, treatment is indicated in those cases with evidence of replication and histological pattern chronic hepatitis necro-inflammatory activity septal fibrosis. Treatment also this group when reactivation occurs after transplant. Up to now lamivudine has been the drug choice transplantation. Adefovir may represent an alternative resistant cases. situation, careful follow-up function required early detection toxicity. Entecavir better initial owing lower risk nephrotoxicity resistance. However, experience management still scarce. The not yet established patients. Ribavirin be option more advanced lesion. It important monitorize hemoglobin levels used. contra-indicated creatinine inferior

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