Molecular cytogenetics of pediatric adipocytic tumors

摘要: Both epidemiologic and cytogenetic data on pediatric adipose tissue tumors are scarce. Pediatric mainly represented by lipomas, though only 28 descriptions of lipoma have been reported to date. Similar adult cases, most these lipomas harbored rearrangements the chromosomal regions 12q14-q15 6p21, involving HMGA2 HMGA1 genes. Further studies would be useful determinate whether some partner genes HMGA2, such as NFIB, may a specific role in early onset tumors. Cytogenetically, best documented tumor is lipoblastoma, which second frequent children. Chromosomal alterations observed 61% cases studied conventional cytogenetics, typically involve 8q11-q12 region. The target gene this rearrangement PLAG1. Anomalies PLAG1 70% molecular cytogenetics methods, fluorescence situ hybridization (FISH) or comparative genomic array (array-CGH). rare described malignant children mostly myxoid liposarcomas. In 27 explored at genetic level, all liposarcomas showed classical DDIT3 12q13. conclusion, epidemiology prevalence histological types differ population compared with adults, whereas genic similar those each type.