Methodological challenges of genome-wide association analysis in Africa

作者: Yik-Ying Teo , Kerrin S. Small , Dominic P. Kwiatkowski

DOI: 10.1038/NRG2731

关键词: GenotypingDiversity (politics)Evolutionary biologyGenome-wide association studyStatistical ImputationGeneticsGenomeMedical researchDNA sequencingBiologyHuman genomeGenetics(clinical)Molecular biology

摘要: Methodological challenges of genome-wide association analysis in Africa | Nature Reviews … Genome-wide and fine-resolution association analysis of malaria in West Africa. Nature …

参考文章(122)
Charles N Rotimi, Georgia M Dunston, Kate Berg, Omobosola Akinsete, Albert Amoah, Samuel Owusu, Joseph Acheampong, Kofi Boateng, Johnnie Oli, Godfrey Okafor, Belonwu Onyenekwe, Babatunde Osotimehin, Fayeofori Abbiyesuku, Thomas Johnson, Olufemi Fasanmade, Paulette Furbert-Harris, Rick Kittles, Mirjana Vekich, Olufemi Adegoke, George Bonney, Francis Collins, None, In Search of Susceptibility Genes for Type 2 Diabetes in West Africa: The Design and Results of the First Phase of the AADM Study Annals of Epidemiology. ,vol. 11, pp. 51- 58 ,(2001) , 10.1016/S1047-2797(00)00180-0
David Modiano, Gaia Luoni, Bienvenu Sodiomon Sirima, Jacques Simporé, Federica Verra, Amadou Konaté, Elena Rastrelli, Anna Olivieri, Carlo Calissano, Giacomo Maria Paganotti, Leila D'Urbano, Issa Sanou, Alphonse Sawadogo, Guido Modiano, Mario Coluzzi, Haemoglobin C protects against clinical Plasmodium falciparum malaria Nature. ,vol. 414, pp. 305- 308 ,(2001) , 10.1038/35104556
Louis H. Miller, Steven J. Mason, David F. Clyde, Mary H. McGinniss, The Resistance Factor to Plasmodium vivax in Blacks New England Journal of Medicine. ,vol. 295, pp. 302- 304 ,(1976) , 10.1056/NEJM197608052950602
Richard S. Cooper, Jay S. Kaufman, Charles N. Rotimi, Eme E. Owoaje, Blood pressure change in Africa: case study from Nigeria. Human Biology. ,vol. 71, pp. 641- 657 ,(1999)
Aarti Agarwal, Aldiouma Guindo, Yacouba Cissoko, James G. Taylor, Drissa Coulibaly, Abdoulaye Koné, Kassoum Kayentao, Abdoulaye Djimde, Christopher V. Plowe, Ogobara Doumbo, Thomas E. Wellems, Dapa Diallo, Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S Blood. ,vol. 96, pp. 2358- 2363 ,(2000) , 10.1182/BLOOD.V96.7.2358
Charles Rotimi, Harold Daniel, Jie Zhou, Augustine Obisesan, Guanjie Chen, Chen Y, Albert Amoah, Victoria Opoku, Acheampong J, Agyenim-Boateng K, Benjamin Ackon Eghan, Johnnie Oli, Okafor G, Ester Ofoegbu, Babatunde Osotimehin, Fayeofori Abbiyesuku, Thomas Johnson, Fasanmade O, Ayo Doumatey, Temilolu Aje, Francis Collins, Georgia Dunston, Prevalence and determinants of diabetic retinopathy and cataracts in West African type 2 diabetes patients. Ethnicity & Disease. ,vol. 13, ,(2003)
W J Ewens, R S Spielman, The transmission/disequilibrium test: history, subdivision, and admixture. American Journal of Human Genetics. ,vol. 57, pp. 455- 464 ,(1995)
S. E. Antonarakis, K. H. Buetow, A. Chakravarti, H. H. Kazazian, P. G. Waber, C. D. Boehm, Nonuniform recombination within the human beta-globin gene cluster. American Journal of Human Genetics. ,vol. 36, pp. 1239- 1258 ,(1984)
Sarah A. Tishkoff, Scott M. Williams, Genetic analysis of African populations: human evolution and complex disease Nature Reviews Genetics. ,vol. 3, pp. 611- 621 ,(2002) , 10.1038/NRG865
Tushar R Bhangale, Mark J Rieder, Deborah A Nickerson, Estimating coverage and power for genetic association studies using near-complete variation data Nature Genetics. ,vol. 40, pp. 841- 843 ,(2008) , 10.1038/NG.180