Interleukin-6 and interleukin-8 concentrations as predictors of outcome in ventricular assist device patients before heart transplantation

摘要: OBJECTIVE To determine whether the serum concentrations of some circulating cytokines (as highly sensitive markers inflammation) are value in predicting outcome patients with cardiogenic shock and end-stage heart disease, who undergo ventricular assist device implantation until transplantation. DESIGN Cohort study. SETTING University teaching hospitals. PATIENTS Twenty or disease were consecutively selected for this study, if was performed as a bridge to MEASUREMENTS AND MAIN RESULTS The interleukin (IL)-1 beta, IL-6, IL-8 tumor necrosis factor (TNF)-alpha monitored from beginning end support two three times week, using commercial enzyme-linked immunosorbent assays (ELISA). In all patients, IL-6 values increased shortly after implantation. uncomplicated courses, decreased an initial increase low at time transplantation, whereas cytokine remained nonsurvivors (survivors vs. nonsurvivors, p < .001). Circulating IL-1 beta TNF-alpha rarely detectable. CONCLUSIONS Monitoring during provides means early identification high-risk that may allow optimization antimicrobial therapy selection appropriate