Proteome-Scale Analysis of Protein S-Acylation Comes of Age.

摘要: Protein S-acylation (commonly known as palmitoylation) is a widespread reversible lipid modification, which plays critical roles in regulating protein localization, activity, stability, and complex formation. The deregulation of contributes to many diseases such cancer neurodegenerative disorders. past decade has witnessed substantial progress proteomic analysis S-acylation, significantly advanced our understanding biology. In this review, we summarized the techniques for enrichment S-acylated proteins or peptides, critically reviewed studies at eight different levels, proposed major challenges S-acylproteomics field. summary, proteome-scale comes age will play increasingly important discovering new disease mechanisms, biomarkers, therapeutic targets.