Functional and Biochemical Evaluation of Platelet Aspirin Resistance After Coronary Artery Bypass Surgery
作者： N. Zimmermann , A. Wenk , U. Kim , P. Kienzle , A.-A. Weber
DOI: 10.1161/01.CIR.0000081770.51929.5A
关键词: Cardiology 、 Cyclooxygenase 、 Aspirin 、 Coronary artery bypass surgery 、 Thromboxane 、 Myocardial infarction 、 Platelet 、 Medicine 、 Stroke 、 Internal medicine 、 Platelet activation
摘要: Background— Aspirin inhibits platelet activation and reduces atherothrombotic complications in patients at risk of myocardial infarction stroke. However, a sufficient inhibition function by aspirin is not always achieved. The causes this resistance are unknown. Methods Results— Patients undergoing coronary artery bypass grafting (CABG) have high incidence resistance. To evaluate functional biochemical responses to aspirin, platelet-rich plasma was obtained before days 1, 5, 10 after CABG. Thromboxane formation, aggregation, α-granule secretion were effectively inhibited 30 or 100 μmol/L vitro CABG, but prevented attenuated Whereas the thromboxane formation aggregation partly recovered day oral (100 mg/d) remained ineffective. inducible isoform cyclooxygenase platelets, COX-2, has been suggested confer res...
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