作者: Jeffrey D. Lee , Sol Perez , He-Jing Wang , Robert A. Figlin , E. Carmack Holmes
关键词: Respiratory disease 、 Medicine 、 Cytarabine 、 Surgery 、 Chemotherapy 、 Decortication 、 Radiation therapy 、 Mesothelioma 、 Cisplatin 、 Mortality rate
摘要: From 1986 to 1993, 15 patients with malignant pleural mesothelioma were treated by pleurectomy/decortication and intrapleural cisplatin (100 mg/ m2) cytosine arabinoside (1,200 mg). All without known extrathoracic disease had a mean age of 63.5 ± 7.9 years (range 51–78); 13 male. Histologic subtype epithelial (47%), sarcomatoid (27%), mixed-biphasic (27%). The major morbidity mortality rates 13% 0%, respectively. length hospital stay was 6.5 2.1 days. Postoperatively, adjuvant chemotherapy radiation therapy given 46% 73% the Median survival from date treatment 11.5 months. Those an histologic experienced significantly improved compared those (P = 0.024). Whether or no significant effect on survival. These data suggest that although this regimen can be administered very limited mortality, role approach in appears cannot currently recommended. © 1995 Wiley-Liss, Inc.