Intravenous ceftriaxone at home versus intravenous flucloxacillin in hospital for children with cellulitis: a cost-effectiveness analysis.

摘要: Summary Background Outpatient parenteral antibiotic therapy after hospital admission is increasingly popular, but its use to avoid altogether by treating patients wholly as outpatients remains uncommon in children. One reason for the low of treatment at home scarcity evidence cost-effectiveness. In this planned follow-up analysis Cellulitis Home or Inpatient Children from Emergency Department (CHOICE) trial, we aimed assess cost-effectiveness an avoidance pathway, which children were treated home, compared with standard care intravenous moderate severe cellulitis. Methods We did a compare ceftriaxone versus flucloxacillin aged 6 months 18 years who had presented emergency department The Royal Children's Hospital, Melbourne, VIC, Australia, uncomplicated included costs two sources: institutional patient level and expenses incurred families. measured effectiveness quality-adjusted life (QALYs), derived Child Health Utility 9D questionnaire, clinical outcome failure, was primary CHOICE trial. calculate incremental ratio, defined difference between groups total cost divided effectiveness. trial registered ClinicalTrials.gov , number NCT02334124 . Findings 180 comprised per-protocol population trial: 89 group 91 group. per episode significantly lower than (AUS$1965 vs $3775; p Interpretation Treatment less costly more effective These findings support development pathway hospitals. Funding Hospital Foundation, Murdoch Research Institute.