Decreased autophosphorylation and kinase activity of insulin receptors in diabetic Chinese hamsters
作者： E. Oshima , K. Watanabe , I. Makino
DOI: 10.1016/0168-8227(90)90079-9
关键词: Insulin-like growth factor 1 receptor 、 Insulin 、 Diabetes mellitus 、 Medicine 、 IRS2 、 Insulin receptor substrate 、 Autophosphorylation 、 Insulin receptor 、 Endocrinology 、 Receptor 、 Internal medicine
摘要: Abstract To clarify the role of insulin receptor in diabetes, hepatic was investigated spontaneously diabetic Chinese hamsters, which are animal models for insulin-deficient diabetes. Insulin binding animals increased mainly due to an increase number receptors. It also observed that both autophosphorylation and kinase activity were decreased compared control animals. These changes may be caused by diabetes itself. As phosphorylated protein 95 kDa immunoprecipitated anti-insulin antibody (B-10, human) diabetics controls, it supposed would β-subunit receptors, as other seem useful examining receptors
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