Adhesion ofEscherichia coliin Urinary Tract Infection

摘要: Abstract In individuals prone to urinary tract infections the intestine is colonized by E. Coli strains that possess a combination of properties determining virulence. Such an coli strain may colonize vaginal and periurethral area ascend tract. The ability attach mucosal surface thought be essential for remain in Most from patients with infection show one or both two adherence properties. One depend on recognition type 1 fimbriae mannose-containing residues slime. It measured as mannose-sensitive haemagglutination found most strains. second property detected attachment human epithelial cells mannose-resistant agglutination erythrocytes. This globo-series glycolipids cell surface. Possession this factor strongly related acute pyelonephritis cystitis have but it rare asymptomatic bacteriuria normal faeces. Local antibodies interfere bacterial attachment, thus possibly preventing colonization precedes modifying established infection. Vaginal are known coat stools. Antibodies urine inhibit infecting uroepithelial cells. directed against several structures, example O antigen fimbriae, likely steric hindrance agglutination. role adhesion-mediating structure such susceptibility outcome remains investigated.