Investigation into the role of P2X3 /P2X2/3 receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study
作者： Caroline J Sharp , Alison J Reeve , Sue D Collins , Jo C Martindale , Scott G Summerfield
关键词: Pharmacology 、 Neuralgia 、 Anesthesia 、 Receptor 、 Central nervous system 、 Nerve injury 、 Antagonist 、 Peripheral neuropathy 、 Spinal cord 、 Neuropathic pain 、 Medicine
摘要: 1. Two P2X(3)/P2X(2/3) receptor antagonists with different potencies were profiled electrophysiologically in a rat model of nerve injury. 2. A-317491 has poor CNS penetrance (blood:brain, 1:<0.05), and was therefore administered intravenously chronic constriction injury (CCI)- sham-operated rats to study the involvement P2X(3) subunit-containing receptors periphery neuropathic pain. Compound A topically spinal cord investigate central contribution. 3. There no significant inhibitory effects intravenous (i.v.) seen animals compared vehicle controls. In CCI-operated animals, there 3 mg kg(-1) i.v. on C fibre-evoked responses, 10 delta responses. No observed after topical application cord. contrast, when spinally CCI decrease wind up. 4. These changes indicate that selective effect neuronal responses sham, demonstrating an increased sensory signalling following addition, more potent antagonist effective spinally, unmasking potential role at this site post data support for modulation
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