Chitosan coated alginate/poly(N-isopropylacrylamide) beads for dual responsive drug delivery.
作者： Ximeng Sun , Jun Shi , Xiaodan Xu , Shaokui Cao
DOI: 10.1016/J.IJBIOMAC.2013.04.066
关键词: Poly(N-isopropylacrylamide) 、 Differential scanning calorimetry 、 Swelling 、 Drug delivery 、 Nuclear chemistry 、 Chitosan 、 Polymer chemistry 、 Thermogravimetric analysis 、 Chemistry 、 Polarized light microscopy 、 Fourier transform infrared spectroscopy
摘要: Abstract Temperature-/pH-responsive chitosan coated alginate/poly(N-isopropylacrylamide) beads (CAPB) were prepared as a drug delivery system. The obtained characterized by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), polarized light microscope (PLM) and electron microscopy (SEM). Oscillation experiments used to analyze the mechanical stability of samples. Effect concentration sodium polyphosphate (SPPP) content on characteristics CAPB was discussed. Swelling release behaviors investigated in simulated intestinal fluid (pH 7.4) gastric 2.1) at 25 °C 37 °C, respectively. Results illustrated that both equilibrium swelling degree (SDeq) greatly affected shell responsive pH temperature. SDeq value decreased with increase concentration; from obviously slower than without coating within 720 min. These developed materials could potentially be sustained dual-responsive device vivo.
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