Mechanisms of action of vitamin D.

作者: Harold E. Harrison

DOI:

关键词: RebuttalRicketsInternal medicineAction (philosophy)PsychotherapistEndocrinologyMedicineVitamin D and neurologyIn patientNormal infantBlood serumHypoparathyroidism

摘要: EVER since the custom was inaugurated so brilliantly by Ashley Weech, President of this society has been given privilege opening meeting with a summary some phase his own research interests and paper is not open to discussion from floor he can theorize bit without restraint possible quick rebuttal. I have chosen discuss work on "Physiology Vitamin D" in which my wife engaged for number years. Since we Baltimore fortunate having benefit Dr. Park9s ideas assistance, inspiration active interest these studies. Research activity field abruptly diminished when practical applications discovery vitamin D resulted virtual disappearance rickets as clinical problem. Many physiological problems remain unsolved, however, our focused mechanism action various sterols activity. In following many important contributions problem are omitted because limitation time. We might first clarify certain quantitative aspects dosage. Figure 1 shows Wide range dosage over used patients. A dose 10 micrograms per day adequate prevention normal infant whereas one five milligrams or more required maintenance patients refractory hypoparathyroidism. It would seem that different biochemical systems be involved at extremes

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