Enhanced sensitivity of bladder cancer cells to cisplatin mediated cytotoxicity and apoptosis in vitro and in vivo by the selective cyclooxygenase-2 inhibitor JTE-522.
作者： YOICHI MIZUTANI , HIROYUKI NAKANISHI , YONG NAN LI , NODOKA SATO , AKIHIRO KAWAUCHI
DOI: 10.1097/01.JU.0000131945.74377.AD
关键词: Cancer cell 、 Cisplatin 、 Cyclooxygenase 、 Immunology 、 Cytotoxicity 、 Cytotoxic T cell 、 Apoptosis 、 Bladder cancer 、 In vivo 、 Medicine 、 Cancer research
摘要: ABSTRACTPurpose: Cyclooxygenase-2 (COX-2) is a key inducible enzyme involved in the production of prostaglandins and its inhibitors have been shown to induce apoptosis various cancer cells. Several anticancer agents also mediate may share common intracellular pathways leading with COX-2 inhibitors. We reasoned that combination treatment bladder cells result synergistic apoptosis. examined whether selective inhibitor JTE-522 (4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide) synergizes cytotoxicity against vitro vivo.Materials Methods: Cytotoxicity was determined by microculture tetrazolium dye assay.Results: Combination T24 cis-diamminedichloroplatinum (II) (CDDP) resulted cytotoxic effect. Synergy achieved ...
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