SMART: identification and annotation of domains from signalling and extracellular protein sequences

摘要: SMART is a simple modular architecture research tool and database that provides domain identification annotation on the WWW (http://coot.embl-heidelberg.de/ ). The compares query sequences with its databases of multiple alignments whilst concurrently identifying compositionally biased regions such as signal peptide, transmembrane coiled coil segments. Annotated unannotated sequence can be used queries in searches databases. alignment collection represents more than 250 signalling extracellular domains. Each curated to assign appropriate boundaries ensure quality. In addition, each annotated extensively respect cellular localisation, species distribution, functional class, tertiary structure functionally important residues.