Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

摘要: Aberrant T-cell activation underlies many autoimmune disorders, yet most attempts to induce tolerance have failed. Building on previous strategies for induction that exploited natural mechanisms clearing apoptotic debris, we show antigen-decorated microparticles (500-nm diameter) long-term in mice with relapsing experimental encephalomyelitis. Specifically, intravenous infusion of either polystyrene or biodegradable poly(lactide-co-glycolide) bearing encephalitogenic peptides prevents the onset and modifies course disease. These beneficial effects require microparticle uptake by marginal zone macrophages expressing scavenger receptor MARCO are mediated part activity regulatory T cells, abortive anergy. Together these data highlight potential using target clearance pathways inactivate pathogenic cells halt disease process autoimmunity.