Pattern Recognition in Legume Lectins to Extrapolate Amino Acid Variability to Sugar Specificity
作者： Nisha Jayaprakash Grandhi , Ashalatha Sreshty Mamidi , Avadhesha Surolia
DOI: 10.1007/978-3-319-11280-0_13
关键词: Structural integrity 、 Amino acid 、 Pattern recognition (psychology) 、 Monosaccharide binding 、 Biochemistry 、 Legume 、 Biology 、 Lectin 、 Sugar 、 Carbohydrate
摘要: Biologic recognition is critical for cell growth, its differentiation and a number of other physiological processes. Lectin carbohydrate interactions mediate regulate these cellular Hence they have attracted lot attention recently. Amongst lectins, those from legumes are the most widely studied. Herein, we report our findings based on influence amino acid constitution in maintaining structural integrity sugar binding specificity lectins. We implemented pattern system represented by heatmaps clustergrams. Percentage identity composition 46 legume lectins were computed to distinguish between different specific derive consensus amongst them. A clear distinction was apparent monosaccharide groups their composition, sequence identities residues combining sites.
springer.com
sci-hub.st 参考文章(71)
The proteomics protocols handbook Humana Press. ,(2005) , 10.1385/1592598900
Nathan Sharon, Irwin Joseph Goldstein, Irvin E. Liener, The Lectins: Properties, Functions and Applications in Biology and Medicine ,(1986)
Robert P. W. Duin, Elżbieta Pekalska, The Science of Pattern Recognition. Achievements and Perspectives Challenges for Computational Intelligence. pp. 221- 259 ,(2007) , 10.1007/978-3-540-71984-7_10
Kartika N. Shetty, Vakada Lavanya Latha, Rameshwaram Nagender Rao, Siva Kumar Nadimpalli, Kaza Suguna, Affinity of a galactose-specific legume lectin from Dolichos lablab to adenine revealed by X-ray cystallography. Iubmb Life. ,vol. 65, pp. 633- 644 ,(2013) , 10.1002/IUB.1177
N.Martin Young, Raymond P. Oomen, Analysis of sequence variation among legume lectins: A ring of hypervariable residues forms the perimeter of the carbohydrate-binding site Journal of Molecular Biology. ,vol. 228, pp. 924- 934 ,(1992) , 10.1016/0022-2836(92)90875-K
Marc R. Wilkins, Elisabeth Gasteiger, Amos Bairoch, Jean-Charles Sanchez, Keith L. Williams, Ron D. Appel, Denis F. Hochstrasser, Protein identification and analysis tools in the ExPASy server Methods of Molecular Biology. ,vol. 112, pp. 531- 552 ,(1999) , 10.1385/1-59259-584-7:531
T Prasthofer, S R Phillips, F L Suddath, J A Engler, Design, expression, and crystallization of recombinant lectin from the garden pea (Pisum sativum). Journal of Biological Chemistry. ,vol. 264, pp. 6793- 6796 ,(1989) , 10.1016/S0021-9258(18)83499-8
Jeffrey D Esko, Ajit Varki, Gerald W Hart, Pamela Stanley, Carolyn R Bertozzi, Richard D Cummings, Marilynn E Etzler, Hudson H Freeze, Essentials of Glycobiology ,(1999)
Nathan Sharon, Halina Lis, Legume lectins — a large family of homologous proteins The FASEB Journal. ,vol. 4, pp. 3198- 3208 ,(1990) , 10.1096/FASEBJ.4.14.2227211
J. A. Hartigan, M. A. Wong, A K-Means Clustering Algorithm Journal of The Royal Statistical Society Series C-applied Statistics. ,vol. 28, pp. 100- 108 ,(1979) , 10.2307/2346830