The important prognostic value of Ki-67 expression as determined by image analysis in breast cancer

摘要: A series of 191 female breast carcinomas (with long-term follow-up) were analysed immunohistochemically a monoclonal MIB1 antibody) for Ki-67 (a proliferation marker) expression with special reference to well-established prognostic factors and patient survival. Expression was directly related the S-phase fraction (P < 0.0001), volume-corrected mitotic index histological grade apoptotic oestrogen progesterose receptor content 0.0001 both) p53 accumulation = 0.001). No correlation found between lymph node status 0.25), metastasis at operation (n 0.81) or tumour size 0.38). The rate, as measured by image analysis expression, predicted survival in entire cohort 0.001) axillary-lymph-node-negative (ANN) patients 0.003). difference recurrence-free high- low-expression groups greatest ANN tumours, 40% 0.008). In axillary-lymph-node-positive not significantly 0.723). results multivariate showed that size, axillary status, independent whereas, cases, labelling factors. These findings imply could be an important determinant cancer. Because evident loss predictive power 1990s, value may even accentuated currently diagnosed small carcinomas.