Hantavirus-Leptospira coinfections in small mammals from central Germany.
作者： C. Imholt , R. G. Ulrich , J. Jacob , M. Pfeffer , G. Heckel
DOI: 10.1017/S0950268821000443
关键词: Leptospira 、 Genotype 、 Coinfection 、 Clade 、 Biology 、 Virology 、 Microtus 、 Hantavirus 、 Puumala orthohantavirus 、 Phylogenetic tree
摘要: European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade (DOBV), genotype Kurkino; Tula (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans. We investigated the frequency of hantavirus single double infections mammals from 22 sites Thuringia, central Germany, during 2017. TULV were detected at 18 (mean prevalence 13.8%, 93/674). PUUV four 1.5%, 7/471), respective sequences formed a novel phylogenetic clade, but DOBV not all. 21 highest overall field voles (Microtus agrestis) 54.5% (6/11) common arvalis) 30.3% (205/676). Leptospira–hantavirus coinfections found 6.6% (44/671) only two 395 bank voles. coinfection probability was driven by individual (age) population-level factors. Coinfections seemed to be particularly associated where exceeded 35%. Future investigations should evaluate public health consequences this strong spatial clustering coinfections.
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