Porphyromonas gingivalis: Gene Cloning of Determinants of Pathogenicity

作者: Barry C. McBride , Umadatt Singh , Angela Joe

DOI: 10.1007/978-1-4615-7087-5_41

关键词: Adult periodontitisBiologyPorphyromonas gingivalisBacteroidesMolecular cloningPathogenesisObligate anaerobeGingival sulcusPathogenicityMicrobiology

摘要: Porphyromonas gingivalis is a frequent isolate from the gingival sulcus of individuals with periodontal disease, and believed to play major role in pathogenesis chronic adult periodontitis (Slots, 1977; Tanner et al., 1979; White Mayrand, 1981). This organism gram-negative, nonmotile, nonspore-forming, obligate anaerobe. Cells are generally cocco-bacillary (0.5 by 1 2 µm) shape. Until recently, P. was known as Bacteroides gingivalis, member asaccharolytic black-pigmented group, but species has now been reclassified (Shah Collins, 1988).

参考文章(121)
Göran Sundqvist, Bacteriological studies of necrotic dental pulps Umea University Odontological Dissertations. ,vol. 7, pp. 5- 94 ,(1976)
B J Moncla, P Braham, K Dix, S Watanabe, D Schwartz, Use of synthetic oligonucleotide DNA probes for the identification of Bacteroides gingivalis. Journal of Clinical Microbiology. ,vol. 28, pp. 324- 327 ,(1990) , 10.1128/JCM.28.2.324-327.1990
M B Wikström, G Dahlén, A Linde, Fibrinogenolytic and fibrinolytic activity in oral microorganisms. Journal of Clinical Microbiology. ,vol. 17, pp. 759- 767 ,(1983) , 10.1128/JCM.17.5.759-767.1983
Jonathan M. Kagan, Local Immunity to Bacteroides gingivalis in Periodontal Disease Journal of Dental Research. ,vol. 59, pp. 1750- 1756 ,(1980) , 10.1177/0022034580059S213
Andrew B. Onderdonk, Bernard J. Mansheim, Dennis L. Kasper, Immunochemical and Biologic Studies of the Lipopolysaccharide of Bacteroides Melaninogenicus Subspecies Asaccharolyticus Journal of Immunology. ,vol. 120, pp. 72- 78 ,(1978)
R E Singer, B A Buckner, Butyrate and propionate: important components of toxic dental plaque extracts. Infection and Immunity. ,vol. 32, pp. 458- 463 ,(1981) , 10.1128/IAI.32.2.458-463.1981
D Grenier, D Mayrand, Selected characteristics of pathogenic and nonpathogenic strains of Bacteroides gingivalis. Journal of Clinical Microbiology. ,vol. 25, pp. 738- 740 ,(1987) , 10.1128/JCM.25.4.738-740.1987
R Parent, C Mouton, L Lamonde, D Bouchard, Human and animal serotypes of Bacteroides gingivalis defined by crossed immunoelectrophoresis. Infection and Immunity. ,vol. 51, pp. 909- 918 ,(1986) , 10.1128/IAI.51.3.909-918.1986