C fragment of lipotropin has a high affinity for brain opiate receptors.

作者: A. F. BRADBURY , D. G. SMYTH , C. R. SNELL , N. J. M. BIRDSALL , E. C. HULME

DOI: 10.1038/260793A0

关键词: In vivoBeta-LipotropinStructure–activity relationshipBiochemistry(+)-NaloxoneFragment (computer graphics)LipotropinChemistryTrypsinPeptide sequence

摘要: THE C-terminal region of lipotropin, named C fragment1, has been found as an intact polypeptide in the pituitary gland2 and fragment is also released from lipotropin by mild digestion with trypsin vitro1. These data suggest that might be elaborated vivo order to perform a physiological function.

参考文章(15)
George R. Stark, Derek G. Smyth, The use of cyanate for the determination of NH2-terminal residues in proteins. Journal of Biological Chemistry. ,vol. 238, pp. 214- 226 ,(1963) , 10.1016/S0021-9258(19)83983-2
Vincent Marks, Polypeptide Hormones: Molecular and Cellular Aspects. Journal of the Royal Society of Medicine. ,vol. 70, pp. 65- 65 ,(1977)
C. B. Pert, G. Pasternak, S. H. Snyder, Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain Science. ,vol. 182, pp. 1359- 1361 ,(1973) , 10.1126/SCIENCE.182.4119.1359
Gavril W. Pasternak, Robert Goodman, Solomon H. Snyder, An endogenous morphine-like factor in mammalian brain. Life Sciences. ,vol. 16, pp. 1765- 1769 ,(1975) , 10.1016/0024-3205(75)90270-2
J. Hughes, T. W. Smith, H. W. Kosterlitz, Linda A. Fothergill, B. A. Morgan, H. R. Morris, Identification of two related pentapeptides from the brain with potent opiate agonist activity Nature. ,vol. 258, pp. 577- 579 ,(1975) , 10.1038/258577A0
D. H. Spackman, W. H. Stein, Stanford. Moore, Automatic recording apparatus for use in the chromatography of amino acids. Analytical Chemistry. ,vol. 17, pp. 1107- 1115 ,(1958) , 10.1021/AC60139A006
B.M. Cox, K.E. Opheim, H. Teschemacher, Avram Goldstein, Purification and properties Life Sciences. ,vol. 16, pp. 1777- 1782 ,(1975) , 10.1016/0024-3205(75)90272-6
Solomon H. Snyder, Opiate receptor in normal and drug altered brain function Nature. ,vol. 257, pp. 185- 189 ,(1975) , 10.1038/257185A0
A. F. BRADBURY, D. G. SMYTH, C. R. SNELL, Biosynthetic origin and receptor conformation of methionine enkephalin. Nature. ,vol. 260, pp. 165- 166 ,(1976) , 10.1038/260165A0