作者: Karina B. Falbo , Xuetong Shen
DOI: 10.1002/JCB.20752
关键词: Cell biology 、 Scaffold/matrix attachment region 、 Mi-2/NuRD complex 、 Biology 、 Genetics 、 ChIA-PET 、 ATP-dependent chromatin remodeling 、 Eukaryotic DNA replication 、 Chromatin remodeling 、 Origin recognition complex 、 Chromatin
摘要: Chromatin remodeling complexes have evolved to solve a very basic problem for eukaryotic cells accommodation of the genome fit dimensions nucleus without loss access DNA molecule. In nucleus, is wrapped around histones form nucleosomes and other higher order compact chromatin structures. enable highly regulated sequences in context chromatin, it well known that these are involved regulation transcription. However, gene expression not only process occurs nucleus. has be replicated, recombined, repaired. this regard, notable recent discoveries linked ATP-dependent damage repair. These results raised challenging questions about possible versatility nuclear activities, particularly replication, since number studies suggested connection between essential cellular remodeling. events regulating replication been extensively investigated. The aim prospect summarize implicate address potential roles at various stages replication.