Subjective improvement in patients with psoriatic arthritis after short-term oral treatment with seal oil. A pilot study with double blind comparison to soy oil.

作者: Tormod Björkkjaer , Tor Magne Madland , Livar Fröyland , Arnold Berstad , Linn Anne Brunborg

DOI:

关键词: ArthritisMedicinePsoriasisSurgerySeverity of illnessInternal medicineRandomized controlled trialPharmacotherapyOral administrationRheumatologyPsoriatic arthritis

摘要: OBJECTIVE: To investigate effects of short-term oral treatment with seal oil in patients psoriatic arthritis (PsA). METHODS: Forty-three polyarticular PsA were randomized to receive for 2 weeks either or soy a double blind controlled trial. Clinical and biochemical variables assessed at baseline, after treatment, 4 post-treatment. Patients allowed continue nonsteroidal antiinflammatory drugs (NSAID) disease modifying antirheumatic (DMARD) during the study. RESULTS: Forty completed study, 20 each group. group reported significant improvement global assessment post- (p

参考文章(16)
J G Brun, R Jonsson, H J Haga, Measurement of plasma calprotectin as an indicator of arthritis and disease activity in patients with inflammatory rheumatic diseases The Journal of Rheumatology. ,vol. 21, pp. 733- 738 ,(1994)
A.P Simopoulos, The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & Pharmacotherapy. ,vol. 56, pp. 365- 379 ,(2002) , 10.1016/S0753-3322(02)00253-6
David Kane, Johannes Roth, Michael Frosch, Thomas Vogl, Barry Bresnihan, Oliver FitzGerald, Increased perivascular synovial membrane expression of myeloid‐related proteins in psoriatic arthritis Arthritis & Rheumatism. ,vol. 48, pp. 1676- 1685 ,(2003) , 10.1002/ART.10988
Dirk Foell, Johannes Roth, Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis & Rheumatism. ,vol. 50, pp. 3762- 3771 ,(2004) , 10.1002/ART.20631
Gülen Arslan, Linn Anne Brunborg, Livar Frøyland, Johan G. Brun, Merete Valen, Arnold Berstad, Effects of duodenal seal oil administration in patients with inflammatory bowel disease. Lipids. ,vol. 37, pp. 935- 940 ,(2002) , 10.1007/S11745-006-0983-2
Jan Brox, Kirsten Olaussen, Bjarne Østerud, Edel O. Elvevoll, Eivin Bjørnstad, Tormod Brenn, Guttorm Brattebø, Hanne Iversen, A long-term seal- and cod-liver-oil supplementation in hypercholesterolemic subjects Lipids. ,vol. 36, pp. 7- 13 ,(2001) , 10.1007/S11745-001-0661-4
Thomas M. Stulnig, Immunomodulation by polyunsaturated fatty acids: mechanisms and effects. International Archives of Allergy and Immunology. ,vol. 132, pp. 310- 321 ,(2003) , 10.1159/000074898
Leslie G Cleland, Michael J James, Susanna M Proudman, The Role of Fish Oils in the Treatment of Rheumatoid Arthritis Drugs. ,vol. 63, pp. 845- 853 ,(2003) , 10.2165/00003495-200363090-00001
Hiroko Yoshida, Jun Kumamaru, Miwa Mawatari, Ikuo Ikeda, Katsumi Imaizumi, Hiroaki Tsuji, Akira Seto, Lymphatic Absorption of Seal and Fish Oils and Their Effect on Lipid Metabolism and Eicosanoid Production in Rats Bioscience, Biotechnology, and Biochemistry. ,vol. 60, pp. 1293- 1298 ,(1996) , 10.1271/BBB.60.1293
T. Fredriksson, U. Pettersson, Severe psoriasis--oral therapy with a new retinoid. Dermatology. ,vol. 157, pp. 238- 244 ,(1978) , 10.1159/000250839