MMP-responsive theranostic nanoplatform based on mesoporous silica nanoparticles for tumor imaging and targeted drug delivery
作者： Jing-Jing Hu , Li-Han Liu , Ze-Yong Li , Ren-Xi Zhuo , Xian-Zheng Zhang
DOI: 10.1039/C5TB02490K
关键词: Nanotechnology 、 Tumor imaging 、 Matrix metalloproteinase 、 Targeted drug delivery 、 Mesoporous silica 、 Endocytosis 、 Fluorescence 、 Materials science 、 Fluorescence-lifetime imaging microscopy 、 Nanoparticle
摘要: In this paper, we report on an intelligent mesoporous silica-based multifunctional theranostic nanoplatform (designated as MMTNP) for tumor imaging well controlled drug release. This consists of MCM-41 typical silica nanoparticles (MSNs) a hydrophobic carrier, matrix metalloprotease-2 (MMP-2) activated fluorescence peptides the surface MSNs served diagnostic probes enzyme-responsive nanovalves blocking pores, and cRGD further functionalized targeting. absence MMP-2 conditions, proximity between fluorescent dye 5(6)-carboxytetramethylrhodamine hydrochloride (TAMRA) quencher 4,4-dimethylamino-azobenzene-4′-carboxylic acid (Dabcyl) resulted in no fluorescence. When loaded arrived at tissue with overexpressed MMP-2, TAMRA became recovered efficiently due to hydrolysis sensitive peptide substrate, realizing triggering addition, introduced significantly enhanced targeting efficiency through receptor-mediated endocytosis cells.
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