Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms.

摘要: The 2001 World Health Organization (WHO) treatise on the classification of hematopoietic tumors lists chronic myeloproliferative diseases (CMPDs) as a subdivision myeloid neoplasms that includes four classic disorders (MPDs)-chronic myelogenous leukemia, polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF)-as well neutrophilic leukemia (CNL), eosinophilic leukemia/hypereosinophilic syndrome (CEL/HES) 'CMPD, unclassifiable'. In upcoming 4th edition WHO document, due out in 2008, term 'CMPDs' is replaced by 'myeloproliferative (MPNs)', MPN category now mast cell disease (MCD), addition to other subcategories mentioned above. At same time, however, with molecularly characterized clonal eosinophilia, previously classified under CEL/HES, are removed from section assembled into new their own. diagnostic criteria for both BCR-ABL-negative MPDs (that PV, ET PMF) CEL/HES have also been revised, 2008 edition, incorporating information molecular pathogenesis. current review highlights these changes provides algorithms tailored routine clinical practice.