Morphine-induced conditioned place preference and associated behavioural plasticity in HIV-1 transgenic rats

摘要: The prevalence of morphine addiction in HIV-1 infected persons is higher than the healthy population. mu-opioid receptor (MOR) which mediates actions shown to be up-regulated transgenic (HIV-1Tg) rat. In this study, we used conditioned place preference (CPP) test investigate if HIV-1Tg rats are more sensitive addictive properties compared F344 control animals. Morphine-CPP was successfully established and at dose 3.5 mg/kg. Interestingly, animals that had paired with one side two-chamber CPP apparatus (the white chamber) failed show any decline for morphine-paired chamber after 17 20 days extinction testing. An analysis change occurs within a session as result habituation exploratory behaviour suggested enhanced natural chamber. We suggest procedure may sometimes behavioural plasticity does not conform predictive learning model classical conditioning reflect form associative known evaluative conditioning. other black showed extinction. Moreover greater resistance observed rats. Following groups were each divided into two groups. One group tested reinstatement following 1 mg/kg prime on 2 consecutive days, respectively. second exposure foot shock. Reinstatement drug-prime or shock stressor observed.