Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging
作者： Yin-Ching I. Chen , Ji-Kyung Choi , Susan L. Andersen , Bruce R. Rosen , Bruce G. Jenkins
DOI: 10.1007/S00213-004-2034-0
关键词: Chemistry 、 Eticlopride 、 Dopamine receptor D3 、 Dopamine receptor D2 、 Magnetic resonance imaging 、 Microdialysis 、 Caudate nucleus 、 Amphetamine 、 Dopamine 、 Neuroscience
摘要: Rationale Regulation of dopamine release and synthesis occurs via pre-synaptic (DA) D2/D3 autoreceptors (DARs). Mapping DAR function in vivo is difficult usually best assessed using invasive measures DA release, such as microdialysis at discrete sites. We wished to show that pharmacological magnetic resonance imaging (phMRI) may prove useful for this purpose.
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