Post-Translational Modification Control of Innate Immunity
作者： Juan Liu , Cheng Qian , Xuetao Cao
DOI: 10.1016/J.IMMUNI.2016.06.020
关键词: Biology 、 Receptor 、 Inflammation 、 Phosphorylation 、 Immunity 、 Ubiquitin 、 Innate immune system 、 SUMO protein 、 Signal transduction 、 Cell biology
摘要: A coordinated balance between the positive and negative regulation of pattern-recognition receptor (PRR)-initiated innate inflammatory responses is required to ensure the most favorable outcome for the host. Post-translational modifications (PTMs) of innate sensors and downstream signaling molecules influence their activity and function by inducing their covalent linkage to new functional groups. PTMs including phosphorylation and polyubiquitination have been shown to potently regulate innate inflammatory responses …
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