Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

作者: T. Shimada , S. Mizutani , T. Muto , T. Yoneya , R. Hino

DOI: 10.1073/PNAS.101545198

关键词: X-linked hypophosphatemiaFibroblast growth factor 23Internal medicineHypophosphatemiaEndocrinologyRenal phosphate excretionChinese hamster ovary cellAutosomal dominant hypophosphatemic ricketsOncogenic osteomalaciaHypophosphatemic RicketsBiology

摘要: … in this RXXR motif of FGF23 are responsible for autosomal dominant … of FGF23 causes TIO, whereas mutations in the FGF23 gene … cleavage and enhancing biological activity of FGF23. …

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