Statin therapy in rheumatoid arthritis.

摘要: Rheumatoid arthritis, a chronic inflammatory polyarthritis that destroys synovial joints, is associated with systemic as well local inflammation and an increased risk of cardiovascular disease death not fully explained by traditional cardiac factors. Statins (HMG-coA reductase inhibitors), medications originally designed to lower cholesterol, have been shown powerful effects on decreasing mortality rates in the general high-risk populations. Not all this protective benefit appears be mediated lowered cholesterol levels. also influence multiple steps process, including leukocyte migration adhesion, T-cell stimulation, nitric oxide bioavailability, generation free radicals, angiogenesis. Recent studies show statins may provide mild anti-inflammatory rheumatoid addition reducing risk.