The role of mast cells and basophils in inflammation.

摘要: Mast cells are positioned in the asthmatic airways so that they able to respond inhaled environment. During active disease, primed secrete an array of preformed and newly generated inflammatory mediators including histamine, neutral proteases heparin sulphate, prostaglandins cysteinyl leukotrienes as well cytokines chemokines involved leucocyte recruitment activation. These a potent source both allergen- exercise-induced asthma possibly provoked by other stimuli such adenosine air pollutants. The important role played mast maintaining airway dysfunction is underpinned efficacy mediator inhibitors, those interfering with release or action leukotrienes, agents inhibit cell activation sodium cromoglycate recently studied E-20 humanized monoclonal antibody binds removes IgE. recent discovery novel inhibitory pathways involving motifs (ITIMS) on critical surface signalling molecules has opened up new possibilities for preventing Future research will focus more effective ways inhibiting cell's contribution understanding what this unique pathogenesis wall remodelling.