Toluquinol, A Marine Fungus Metabolite, Inhibits Some of the Hallmarks of Cancer

摘要: Ten general hallmarks of cancer have been proposed so far: sustaining proliferative signaling, evading growth suppressors, resisting apoptosis, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, genome instability mutation, tumor promoting inflammation, avoiding immune destruction deregulating cellular energetic. Targeting the mentioned “hallmarks” in a can block cancer’s ability to grow metastasize. Thus, better understanding biology has allowed development targeted therapies numerous patients benefited far. The best strategy would be use drugs or drug combinations that target multiple at same time. chemical biological diversity marine environment is being exploited aiming discover new anticancer drugs. Toluquinol an example compound with antitumor properties. Isolated from fungus Penicillium sp. HL-85-ALS5-R004, this inhibits proliferation actively growing cells, blocks angiogenesis vitro vivo, induces apoptosis endothelial cells. Taken together, these data indicate toluquinol several cancer, essential for progression invasion, underscoring its potential pharmacological utility therapies.