Immunoglobulin IgG Abnormalities and the Oligoclonal Pattern of IgG in Multiple Sclerosis Brains

摘要: Elevated IgG distributed in oligoclonal bands is often observed the CSF of MS patients. There evidence that abnormal patients derived from intrathecal production. Already 1967 Tourtellotte et al. reported elevated concentrations both plaques and apparently normal white grey matter brains. Other studies brains have confirmed existence unbound plaque non-plaque material (Link, 1972; Gilden al., 1977; Mehta 1981). Furthermore cell surface-bound can also be eluted with help acid or alkaline extraction brain (Gilden 1979; Isoelectrofocussing (IEF) combination immunofixation (IF) extracts has frequently revealed an pattern Mattson 1980;