Tramadol and acetaminophen tablets for dental pain.

摘要: The purpose of this work was to compare the efficacy and time analgesia a new tramadol/acetaminophen combination tablet those tramadol or acetaminophen (APAP) alone. A meta-analysis performed 3 separate single-dose, double-blind, parallel-group trials in patients with moderate severe pain following extraction 2 more third molars. Patients each study were evenly randomized single dose tramadol/APAP (75 mg/650 mg), 75 mg, APAP 650 ibuprofen 400 placebo. Active control used determine model sensitivity. Pain relief (scale, 0-4) intensity 0-3) reported at 30 minutes after then hourly for 8 hours. Total over hours (TOTPAR8) sum differences (SPID8) calculated from scores. Time onset determined by double-stopwatch technique, advised wait least before taking supplemental analgesia. assessed overall 1-5) upon completion. In all, 1197 (age range, 16-46 years) evaluable efficacy; treatment groups similar baseline. superior placebo (P < = .0001) all treatments. provided tramadol/ that alone, as shown mean TOT-PAR8 (12.1 vs 6.7 8.6, respectively, P SPID8 (4.7 0.9 2.7, .0001). Estimated 17 (95% CI, 15-20 minutes) compared 51 40-70 tramadol, 18 16-21 APAP, 34 28-44 ibuprofen. Median assessment greater .05) group (302 3.0, respectively) than (122 2.0) (183 2.7) monotherapy groups. analgesic, tramadol/APAP, is alone respect duration action. It also onset.