[Ru2II(ttha)(H2O)2]2− is a rapid No scavenger (ttha6− = triethylenetetraminehexaacetate)

摘要: Abstract The reaction of NO(aq.) with [Ru 2 II (ttha)(H O) ] 2− = (A) and (ttha) (bpy) (H O)] (B), (ttha 6− triethylenetetraminehexaacetate; bpy 2.2′-bipyridine) was monitored by electrochemical methods (cyclic voltammetry, differential pulse polarography). Each two sites (ttha)] may be represented [LRu] for convenience. Waves the [LRu (NO·)] → −1e− (NO + )], 2[LRu − )] −2e− III 3 oxidations were identified at −0.06, +0.98, 1.14 V vs normal hydrogen electrode, respectively. protonated form (NO·)], (NOH)], detected as a separate Ru II/III wave +0.10 V. pK (NOH)] is 1.80. rate substitution NO on 22.7 M −1 s 22°C indicating neutral ligand -polyaminopolycarboxylates via dissociative intermediates. identical waves nitrosylated (B) indicate that nitrosyls (A), [(Ru (NO)·)) (C), are terminally coordinated rather than single bridged nitrosyl. nitrosyl (C) does not react H , precluding catalytic scavenging followed reduction environmental control purposes. However, robust dissociates very slowly under Ar purging. Thus parent complex related mononuclear such [Ru(hedta)(H have several features lend them toward uses antisepsis agents septic shock. also reacts directly NO, forming )) which exhibits same (ttha)(NO) since ) units readily reduce electrochemically glassy carbon to (NO·) below −0.06 It observed catalyzes oxidation and, hence HNO carbon.