作者: G CASADESUS , B SHUKITTHALE , J JOSEPH
DOI: 10.1016/S0197-4580(02)00079-9
关键词: Generalization (learning) 、 Parkinson's disease 、 Oxidative stress 、 Successful aging 、 Neuroscience 、 Alzheimer's disease 、 Medicine 、 Senescence 、 Disease 、 Population 、 Gerontology
摘要: With the increasing demands placed on our society to perform better for longer, in addition large increase old segment of population, a race has begun forestall or reverse ubiquitous declines that emerge from growing old. Currently, little is known about mechanisms responsible neuronal degeneration seen during both normal aging and neurodegenerative disease; however, among prime candidates producing these effects are free radicals. It been hypothesized brain results progressive inability cope with such insults as oxidative stress inflammation. As result, this provides fertile environment subsequent development disease. Therefore, if preservation function associated cognitive motor performance will enhance probability successfully, then it crucial importance find ways preserve decrease responsiveness insults. The purpose review discuss two strategies, caloric restriction antioxidant supplementation (through foods supplements), proven be successful at protecting age-related interventions compared contrasted terms their effectiveness, safety, generalization capacity human treatment.