Association between epithelial-mesenchymal transition and cancer stemness and their effect on the prognosis of lung adenocarcinoma.
作者： Terumasa Sowa , Toshi Menju , Makoto Sonobe , Takao Nakanishi , Kei Shikuma
DOI: 10.1002/CAM4.556
关键词: Internal medicine 、 Vimentin 、 Lung cancer 、 Tumor progression 、 Cancer 、 Medicine 、 Epithelial–mesenchymal transition 、 CD44 、 Oncology 、 Adenocarcinoma 、 Metastasis
摘要: The epithelial-mesenchymal transition (EMT) and cancer stemness (CS) are reported to be pivotal phenomena involved in metastasis, recurrence, drug-resistance lung cancer; however, their effects on tumor malignancy clinical settings not completely understood. mutual association between these factors also remains elusive worthy of investigation. purpose this study was elucidate the EMT CS, effect prognosis patients with adenocarcinoma. A total 239 adenocarcinoma specimens were collected from who had undergone surgery at Kyoto University Hospital January 2001 December 2007. Both (E-cadherin,vimentin) CS (CD133, CD44, aldehyde dehydrogenase) markers analyzed through immunostaining specimens. as well patients' information integrated statistically analyzed. molecular expression E-cadherin, vimentin, CD133 significantly correlated (P = 0.003, P 0.005, < 0.001). negative correlation found E-cadherin vimentin 0.001), whereas, a positive 0.020). stronger prognostic factor than an marker. Elevated is signature marker associated Importantly, suggested key that links thereby exacerbating progression.
core.ac.uk
sci-hub.se 参考文章(45)
Amy H. Yin, Sheri Miraglia, Esmail D. Zanjani, Graca Almeida-Porada, Makio Ogawa, Anne G. Leary, Johanna Olweus, John Kearney, David W. Buck, AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor Cells Blood. ,vol. 90, pp. 5002- 5012 ,(1997) , 10.1182/BLOOD.V90.12.5002
Zhuang Luo, Peng Li, Qing-Lin Hao, Li-Yan Zhang, Rong-Rong Wu, Wei Li, Liang Lv, Prognostic value of CD44 expression in non-small cell lung cancer: a systematic review. International Journal of Clinical and Experimental Pathology. ,vol. 7, pp. 3632- 3646 ,(2014)
Mary K. Gospodarowicz, Leslie H. Sobin, C. Wittekind, Comprar TNM Classification of Malignant Tumours, 7th Edition | C. Wittekind | 9781444332414 | Wiley Wiley. ,(2009)
Akihiko Yoshizawa, Shinji Sumiyoshi, Makoto Sonobe, Masashi Kobayashi, Takeshi Uehara, Masakazu Fujimoto, Tatsuaki Tsuruyama, Hiroshi Date, Hironori Haga, HER2 status in lung adenocarcinoma: A comparison of immunohistochemistry, fluorescence in situ hybridization (FISH), dual-ISH, and gene mutations Lung Cancer. ,vol. 85, pp. 373- 378 ,(2014) , 10.1016/J.LUNGCAN.2014.06.007
Yoshinobu Toda, Katsuhiko Kono, Hitoshi Abiru, Kumiko Kokuryo, Mareyuki Endo, Hiroshi Yaegashi, Manabu Fukumoto, Application of tyramide signal amplification system to immunohistochemistry: A potent method to localize antigens that are not detectable by ordinary method Pathology International. ,vol. 49, pp. 479- 483 ,(1999) , 10.1046/J.1440-1827.1999.00875.X
Tomoyuki Goya, Hisao Asamura, Hirokuni Yoshimura, Harubumi Kato, Kaoru Shimokata, Ryosuke Tsuchiya, Yasunori Sohara, Toshimichi Miya, Etsuo Miyaoka, Japanese Joint Committee of Lung Cancer Registry, None, Prognosis of 6644 resected non-small cell lung cancers in Japan: A Japanese lung cancer registry study Lung Cancer. ,vol. 50, pp. 227- 234 ,(2005) , 10.1016/J.LUNGCAN.2005.05.021
K Vuoriluoto, H Haugen, S Kiviluoto, J-P Mpindi, J Nevo, C Gjerdrum, C Tiron, J B Lorens, J Ivaska, Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer Oncogene. ,vol. 30, pp. 1436- 1448 ,(2011) , 10.1038/ONC.2010.509
Yusuke Ohara, Tatsuya Oda, Masato Sugano, Shinji Hashimoto, Tsuyoshi Enomoto, Keiichi Yamada, Yoshimasa Akashi, Ryoichi Miyamoto, Akihiko Kobayashi, Kiyoshi Fukunaga, Yukio Morishita, Nobuhiro Ohkohchi, Histological and prognostic importance of CD44(+) /CD24(+) /EpCAM(+) expression in clinical pancreatic cancer. Cancer Science. ,vol. 104, pp. 1127- 1134 ,(2013) , 10.1111/CAS.12198
Tao-Tao Dong, Hou-Min Zhou, Lin-Lin Wang, Bo Feng, Bo Lv, Min-Hua Zheng, Salinomycin Selectively Targets ‘CD133+’ Cell Subpopulations and Decreases Malignant Traits in Colorectal Cancer Lines Annals of Surgical Oncology. ,vol. 18, pp. 1797- 1804 ,(2011) , 10.1245/S10434-011-1561-2
Joana Monteiro, Riccardo Fodde, Cancer stemness and metastasis: therapeutic consequences and perspectives. European Journal of Cancer. ,vol. 46, pp. 1198- 1203 ,(2010) , 10.1016/J.EJCA.2010.02.030