bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

摘要: Abstract The chromosome translocation forming the hybrid bcr-abl gene is thought to be initiating event in chronic myeloid leukaemia (CML) and some cases of acute lymphoblastic leukaemia. To assess impact upon haemopoiesis, lethally irradiated mice were reconstituted with bone marrow cells enriched for cycling stem infected a bearing retrovirus. The developed several fatal diseases abnormal accumulations macrophage, erythroid, mast lymphoid cells, marked strain differences disease distribution kinetics. Some exhibited more than one neoplastic cell type and, instances, these clonally related, indicating that progenitor or had been transformed. While classical CML was not observed, macrophage tumours accompanied by mild CML-like syndrome, probably due growth factor production tumour cells. erythroid rarely transplantable, contrast lymphomas, but all types displayed limited clonality. These results establish confers proliferative advantage on diverse haemopoietic complete transformation involves additional genetic changes.